Table 1 Small-molecule drugs used in the Liver-Chip evaluation.
From: Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology
Drug | IQ MPS list | Tested in spheroid | Spheroid false negative | Garside DILI rank |
|---|---|---|---|---|
Ambrisentan | Yes, matched with Sitaxsentan | Yes | No | 5 |
Asunaprevir | Yes, no matched pair | No | No | 2 |
Benoxaprofen | No | Yes | Yes | 1 |
Beta-Estradiol | No | Yes | Yes | 3 |
Buspirone | Yes, matched with Nefazodone | Yes | No | 4 |
Chlorpheniramine | No | Yes | Yes | 3 |
Clozapine | Yes, matched with Olanzapine | Yes | No | 2 |
Diclofenac | Yes, no matched pair | Yes | No | 2 |
Entacapone | Yes, matched with Tolcapone | Yes | No | 4 |
Fialuridine | Yes, matched with FIRU | Yes | No | 1 |
FIRU | Yes, matched with Fialuridine | No | No | 5 |
Labetalol | No | Yes | Yes | 1 |
Levofloxacin | Yes, matched with Trovafloxacin | Yes | Yes | 2 |
Lomitapide | No, Mipomersen substitute | No | No | 3 |
Nefazodone | Yes, matched with Buspirone | Yes | No | 1 |
Yes, matched with Clozapine | No | No | 5 | |
Pioglitazone | Yes, matched with Troglitazone | Yes | Yes | 3 |
Simvastatin | No | Yes | Yes | 2 |
Sitaxsentan | Yes, matched with Ambrisentan | Yes | No | 1 |
Stavudine | No | Yes | Yes | 1 |
Tacrine | No | Yes | Yes | 2 |
Telithromycin | Yes, no matched pair | No | No | 1 |
Tolcapone | Yes, matched with Entacapone | Yes | No | 1 |
Troglitazone | Yes, matched with Pioglitazone | Yes | No | 1 |
Trovafloxacin | Yes, matched with Levofloxacin | Yes | No | 1 |
Ximelagatran | No | Yes | Yes | 1 |
Zileuton | Yes, no matched pair | Yes | Yes | 2 |
