Table 4 Calculation of margin of safety (MOS)-like figures.
From: Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology
Drug | Chip MOS donor 1 | Chip MOS donor 2 | Chip MOS both donors | Spheroid MOS |
|---|---|---|---|---|
Ambrisentan | >3 | >10 | >10 | >127 |
Asunaprevir | 4 | – | – | – |
Benoxaprofen | 0.001 | 0.3 | 0.001 | >0.7 |
Beta-Estradiol | >5 | – | – | 22,500 |
Buspirone | >15 | – | – | 16,300 |
Chlorpheniramine | >200 | – | – | 2141 |
Clozapine | 1.8 | 5 | 1.8 | 14.5 |
Diclofenac | 1.8 | – | – | 6.1 |
Entacapone | >6 | – | – | 46.5 |
Fialuridine | 0.1 | 2.8 | 0.1 | 12.3 |
FIRU | >108 | >108 | >108 | – |
Labetalol | 26 | 22 | 22 | 0.41 |
Levofloxacin | >11.3 | >33.7 | >33.7 | >20 |
Lomitapide | 0 | – | – | – |
Nefazodone | 1.4 | – | – | 6.8 |
Olanzapine | >20 | >2 | >20 | – |
Pioglitazone | 2.8 | > 2.8 | 2.8 | > 5.3 |
Simvastatin | 17 | 45 | 17 | 460 |
Sitaxsentan | 0.04 | 1.6 | 0.04 | 8.7 |
Stavudine | 247 | 107 | 107 | >144 |
Tacrine | >12 | >12 | >12 | 696 |
Telithromycin | 6 | – | – | – |
Tolcapone | 0.004 | 0.05 | 0.004 | 0.3 |
Troglitazone | 0.03 | 0.1 | 0.03 | 2.3 |
Trovafloxacin | 20 | 19 | 19 | >24.9 |
Ximelagatran | 30 | 300 | 30 | 335 |
Zileuton | >7 | 15 | 15 | >7.7 |
