Fig. 2: Venn diagram and volcano plots illustrating the number, degree and significance of differential protein expression in the 1st cohort. | Communications Medicine

Fig. 2: Venn diagram and volcano plots illustrating the number, degree and significance of differential protein expression in the 1st cohort.

From: Discovery and systematic assessment of early biomarkers that predict progression to severe COVID-19 disease

Fig. 2

The volcano plots visualize the p values (adjusted for multiple testing) and corresponding log-fold changes (logFC) of the identified protein biomarker candidates. A significance level of adj. p value = 0.05 is indicated as a horizontal red line. Absolute logFC cutoffs of |logFC | > 0.5 are indicated as vertical lines. 53 plasma samples from 16 COVID-19 patients were analyzed and divided into an acute (a) an intermediate (b) and a late stage (c), for which we included 18, 20 and 16 samples, respectively. Proteins with a positive logFC had a higher abundance in CS samples, proteins with a negative value in MM samples. d: Venn diagram listing the differential proteins and their numbers in the respective phases. Green numbers and protein IDs indicate proteins more abundant in CS patients and red numbers and IDs proteins with higher abundance in MM patients.

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