Table 1 Association between MR values, disease symptoms, enzyme activity, and histopathological measurements.
| Ā | Hyperpolarized [13C]Lac/Pyr | Hyperpolarized [13C]urea | T1 contrast enhancement |
|---|---|---|---|
Disease symptomsa | |||
Ā Ā EAE score | |||
Ā Ā Ā Ā Pearsonās r | rā=ā0.45 | rā=āā0.05 | rā=ā0.79 |
Ā Ā Ā Ā p-value | pā=ā0.0094 (**) | pā=ā0.77 | pā<ā0.0001 (****) |
Enzyme activityb | |||
Ā Ā PDH | |||
Ā Ā Ā Ā Equation | Yā=āā0.00074Xā+ā0.0001 | Yā=ā0.00012Xāāā5e-005 | Yā=āā5.9e-006Xā+ā5e-005 |
Ā Ā Ā Ā r2 | r2ā=ā0.97 | r2ā=ā0.10 | r2ā=ā0.50 |
Ā Ā Ā Ā p-value | pā=ā0.014 (*) | pā=ā0.69 | pā=ā0.29 |
Ā Ā LDH | |||
Ā Ā Ā Ā Equation | Yā=āā0.00073Xā+ā0.00031 | Yā=ā0.00024Xā+ā7e-005 | Yā=ā2.03e-007Xā+ā0.0002 |
Ā Ā Ā Ā r2 | r2ā=ā0.30 | r2ā=ā0.13 | r2ā=ā0.00 |
Ā Ā Ā Ā p-value | pā=ā0.46 | pā=ā0.64 | pā=ā0.98 |
Immunofluorescence analysesb | |||
Ā Ā Iba1 | |||
Ā Ā Ā Ā Equation | Yā=ā330Xāāā16 | Yā=āā18Xā+ā30 | Yā=ā2.9Xā+ā7 |
Ā Ā Ā Ā r2 | r2ā=ā0.98 | r2ā=ā0.01 | r2ā=ā0.60 |
Ā Ā Ā Ā p-value | pā=ā0.013 (*) | pā=ā0.89 | pā=ā0.23 |
Ā Ā PDK1 | |||
Ā Ā Ā Ā Equation | Yā=ā209Xāāā13 | Yā=ā9Xā+ā1 | Yā=ā2.1Xā+ā0.3 |
Ā Ā Ā Ā r2 | r2ā=ā0.92 | r2ā=ā0.01 | r2ā=ā0.73 |
Ā Ā Ā Ā p-value | pā=ā0.041 (*) | pā=ā0.92 | pā=ā0.15 |
Ā Ā CD68 | |||
Ā Ā Ā Ā Equation | Yā=ā194Xāāā11 | Yā=āā16Xā+ā20 | Yā=ā1.3Xā+ā4 |
Ā Ā Ā Ā r2 | r2ā=ā0.83 | r2ā=ā0.02 | r2ā=ā0.32 |
Ā Ā Ā Ā p-value | pā=ā0.09 | pā=ā0.84 | pā=ā0.44 |
Ā Ā CD3 | |||
Ā Ā Ā Ā Equation | Yā=ā302X ā 6 | Yā=āā95Xā+ā90 | Yā=ā2.4Xā+ā16 |
Ā Ā Ā Ā r2 | r2ā=ā0.81 | r2ā=ā0.33 | r2ā=ā0.42 |
Ā Ā Ā Ā p-value | pā=ā0.10 | pā=ā0.43 | pā=ā0.35 |
Ā Ā Fibrinogen | |||
Ā Ā Ā Ā Equation | Yā=ā21X ā 1.4 | Yā=ā0.25Xā+ā1 | Yā=ā0.3Xāāā0.3 |
Ā Ā Ā Ā r2 | r2ā=ā0.59 | r2ā=ā0.00 | r2ā=ā0.94 |
Ā Ā Ā Ā p-value | pā=ā0.19 | pā=ā0.98 | pā=ā0.027 (*) |
Ā Ā GFAP | |||
Ā Ā Ā Ā Equation | Yā=ā296Xāāā5.4 | Yā=āā88Xā+ā85 | Yā=ā2Xā+ā18 |
Ā Ā Ā Ā r2 | pā=ā0.12 | r2ā=ā0.28 | r2ā=ā0.20 |
Ā Ā Ā Ā p-value | r2ā=ā0.77 | pā=ā0.47 | pā=ā0.56 |
Ā Ā Myelin | |||
Ā Ā Ā Ā Equation | Yā=āā284Xā+ā73 | Yā=ā66Xāāā1 | Yā=āā1Xā+ā50 |
Ā Ā Ā Ā r2 | r2ā=ā0.72 | r2ā=ā0.16 | r2ā=ā0.16 |
Ā Ā Ā Ā p-value | pā=ā0.15 | pā=ā0.60 | pā=ā0.61 |
T1 contrast enhancementa | |||
Ā Ā Ā Ā Pearsonās r | rā=ā0.54 | rā=āā0.07 | Not applicable |
Ā Ā Ā Ā p-value | pā=ā0.0028 (**) | pā=ā0.73 | Not applicable |