Table 3 Relation of ET-1 level and disease outcomes.

From: Endothelin-1 is associated with mortality that can be attenuated with high intensity statin therapy in patients with stable coronary artery disease

 

Univariable analysis

Multivariable analysis (model 3)

 

Hazard Ratio

p-value

Trend p

Hazard Ratio

p-value

Trend p

All-cause mortality

  ET-1 (Q2)

1.19 (0.71–2.02)

0.507

<0.001

0.95 (0.55–1.61)

0.838

<0.001

  ET-1 (Q3)

2.29 (1.44–3.65)

<0.001

1.37 (0.84–2.23)

0.201

  ET-1 (Q4)

4.45 (2.89–6.83)

<0.001

2.01 (1.26–3.23)

0.004

CV deatha

  ET-1 (Q2)

1.36 (0.66–2.79)

0.408

<0.001

1.01 (0.48–2.14)

0.979

0.056

  ET-1 (Q3)

2.65 (1.4–5.04)

0.003

1.43 (0.72–2.85)

0.302

  ET-1 (Q4)

4.47 (2.44–8.2)

<0.001

1.49 (0.74–2.98)

0.260

non-CV death

  ET-1 (Q2)

1.11 (0.52–2.37)

0.781

<0.001

0.93 (0.44–1.98)

0.848

<0.001

  ET-1 (Q3)

1.85 (0.94–3.65)

0.076

1.26 (0.63–2.52)

0.513

  ET-1 (Q4)

4.41 (2.4–8.1)

<0.001

2.63 (1.39–4.98)

0.003

SCDa

  ET-1 (Q2)

1.21 (0.41–3.61)

0.729

<0.001

0.99 (0.31–3.2)

0.989

0.106

  ET-1 (Q3)

2.78 (1.09–7.1)

0.033

1.91 (0.68–5.4)

0.223

  ET-1 (Q4)

3.81 (1.54–9.45)

0.004

1.67 (0.56–4.93)

0.356

  1. aFor CV death and SCD, ET-1 quartile (as categorical variable) was not able to enter model 3 with forward-AIC selection or enter model S4. Therefore, shown are multivariable adjustment with all variables in model 3 but entering model together. The 1st quartile of ET-1 (Q1) was used as reference. ET-1 endothelin-1, CV death cardiovascular death, non-CV death non-cardiovascular death, SCD sudden cardiac death
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