Table 4 Statins and risk for all-cause mortality and CV death in high ET-1 group.

	Univariable analysis		Multivariable analysis (model 3)
High ET-1	Hazard Ratio	p-value	Hazard Ratio	p-value
All-cause mortality
no statins	reference		reference
statins (low)	0.96 (0.41–2.23)	0.926	0.78 (0.33–1.82)	0.567
statins (moderate)	0.8 (0.48–1.36)	0.415	0.76 (0.45–1.3)	0.32
statins (high)	0.13 (0.03–0.58)	0.007	0.05 (0.01–0.38)	0.004
CV Death
no statins	reference		reference
statins (low)	0.76 (0.27–2.12)	0.603	0.54 (0.19–1.52)	0.241
statins (moderate)	0.46 (0.25–0.85)	0.013	0.38 (0.2–0.71)	0.002
statins (high)	0.17 (0.04–0.73)	0.018	0.06 (0.01–0.44)	0.006

Low intensity statin group consist of simvastatin 10 mg, pravastatin 10 mg, pravastatin 20 mg, fluvastatin 20 mg and fluvastatin 40 mg; Moderate intensity statin group contains simvastatin 20 mg, simvastatin 30 mg, simvastatin 40 mg, rosuvastatin 5 mg, rosuvastatin 10 mg, atorvastatin 10 mg, atorvastatin 20 mg, pravastatin 40 mg, pravastatin 80 mg, fluvastatin 80 mg and lovastatin 40 mg; High intensity statin group comprises atorvastatin 40 mg, atorvastatin 80 mg, rosuvastatin 20 mg and rosuvastatin 40 mg. ET-1 endothelin-1, LDL low-density lipoprotein, CV death cardiovascular death.

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