Table 2 Gynecological tumors reported in xeroderma pigmentosum patients.
Tumor typesa (patient code) | Country of patient’s origin | Age at tumor diagnosis (years) | Age at death (years) | Gene mutation | References |
|---|---|---|---|---|---|
Uterine carcinoma | Japan | 49 | 51 | ni | Satoh Ok& Nishigori 198830 |
Uterine adenocarcinoma (XP1BE) | USA | ni | 49 | XPC: c.1132_1133 delAA | Khan et al 200631 |
Cervical sarcoma (XP269VI) | Morocco | 18 | 23 | XPC: delTGb | Hadj-Rabia et al 201332 |
Uterine leiomyosarcoma | Tunisia | 19 | 19 | XPC: delTG | Jerbi et al 201633 |
Uterine leiomyosarcoma | Tunisia | 22 | 29 | XPC: delTG | Jerbi et al 201633 |
Ovarian mature cystic teratoma | China | 28 | ni | XPC: HZ c.2218_2220delCTC; p.Glu740_740del HZ c.2257dupC; p.Arg753fs | Tang et al 201834 |
Serous ovary Carcinoma | Brazil | 27 | Alive | XPC: delTG | Santiago et al 202035 |
Uterine rhabdomyosarcomc (XP2004VI) | Algeria | 16 | 22 | XPC: delTG | Yurchenko et al 20202 This work |
Uterine rhabdomyosarcomc (XP2003VI) | Algeria | 16 | Alive | XPC: delTG | This work |
Ovarian sarcoma (XPElHaVI)d | Morocco | 18 | 22 | XPC: delTG | Nikolaev et al 20221 |
Uterine adenosarcoma (XPElKaVI)d | Morocco | 15 | Alive | XPC: delTG | Nikolaev et al 20221 |
Sertoli-Leydig cell tumor (XP2020VI) | Tunisia | 11 | Alive | XPC: HZ delTG HZ c.G850T; p.E284X | This work |
2 independent ovarian tumors in the same patient: (a) Juvenile granulosa-cell tumor of the ovary (left) (b) Sertoli-Leydig cell tumor (right) (XP694VI) | North Africa | 19 | Alive | XPC: delTG | This work |
Sertoli-Leydig tumor left | Tunisia | 27 | Alive | ni | Bdioui et al 202136 |
Sex-cord stromal tumor | Tunisia | 7 | Dead | ni | Bacha et al 201937 |
