Fig. 2: Neurodevelopmental and growth outcomes based on presence of a damaging genetic variant: distribution of Psychomotor Developmental Index (PDI), Mental Developmental Index (MDI), and length for age z-score (LAZ) for those individuals with and without a damaging genetic variant, defined by GEM Bayes Factor ≥0.69. | Communications Medicine

Fig. 2: Neurodevelopmental and growth outcomes based on presence of a damaging genetic variant: distribution of Psychomotor Developmental Index (PDI), Mental Developmental Index (MDI), and length for age z-score (LAZ) for those individuals with and without a damaging genetic variant, defined by GEM Bayes Factor ≥0.69.

From: Genetic and clinical variables act synergistically to impact neurodevelopmental outcomes in children with single ventricle heart disease

Fig. 2

a Box plots of MDI, PDI and LAZ scores in participants with (+) and without (−) a damaging variant in a gene related to the HPO term “Abnormal Heart Morphology”; N = 167 participants without damaging genotype, N = 137 participants with damaging genotype. None of the comparisons achieved statistical significance after corrections for multiple testing: p = 0.94, MDI; p = 0.14, PDI; p = 0.94, LAZ. b Box plots of MDI, PDI and LAZ scores in participants with a damaging genotype in a known syndromic CHD gene (N = 38) and without (N = 167). Center horizontal line, mean value; box, 1 standard deviation; whiskers, 5 and 95th percentiles. None of the comparisons achieved statistical significance after corrections for multiple testing: p = 0.68, MDI; p = 0.15, PDI; p = 0.08, LAZ.

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