Table 5 Efficacy of T2D preventive interventions according to molecular effect modifiers.

From: Impact of individual and environmental factors on dietary or lifestyle interventions to prevent type 2 diabetes development: a systematic review

 

T2D preventive strategies

Lifestyle intervention

Dietary pattern intervention

Modifier

Number of studies

Effect modificationa

Certainty of evidenceb

Number of Studies

Effect modificationa

Certainty of evidenceb

T2D single SNPs

17

Yes: 9 studies

No: 7 studies

Not reported: 1 study

Grade D

1

Yes: 1 study

Grade D

Diabetes polygenic score

5

Yes: 1 study

No: 4 studies

Grade D

–

–

–

Metabolites/miRNA

–

–

–

3

Yes: 3 studies

Grade D

  1. Overview of the included studies investigating whether genetic and molecular factors at baseline modify the response to T2D preventive intervention strategies.
  2. aYes/No corresponds to significant/nonsignificant effect modification, as reported in the study.
  3. bCertainty of evidence denotes consistency, Grading based on Diabetes Canada scale A to D.
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