Table 2 Oral pharmacological agent adequate to achieve target glucose levels vs need for escalation to insulin to achieve glucose targets.
From: Precision gestational diabetes treatment: a systematic review and meta-analyses
Precision Marker | Studies | Participants | Statistical method | Effect Estimate (95%CI) | GRADE |
|---|---|---|---|---|---|
Age (years) | 11 | 1473 | Mean difference (95%CI) | −1.04 [−2.10, 0.03] | ⊕⊕◯◯ |
Nulliparity | 8 | 1215 | Odds Ratio (95%CI) | 1.55 [1.17, 2.04] | ⊕⊕◯◯ |
Body mass index (kg/m2) | 10 | 1692 | Mean difference (95%CI) | −1.21 [−2.21, −0.21] | ⊕⊕◯◯ |
Previous history of GDM | 8 | 1412 | Odds Ratio (95%CI) | 0.43 [0.30, 0.63] | ⊕⊕◯◯ |
Haemoglobin A1C (%) | 6 | 1152 | Mean difference (95%CI) | −0.21 [−0.29, −0.13] | ⊕⊕◯◯ |
Fasting glucose (mg/dl) | 12 | 1836 | Mean difference (95%CI) | −8.02 [−11.87, −4.16] | ⊕◯◯◯ |
1-h glucose (mg/dl) | 8 | 1177 | Mean difference (95%CI) | −10.64 [−18.25, −3.02] | ⊕◯◯◯ |
2-h glucose (mg/dl) | 10 | 1378 | Mean difference (95%CI) | −7.31 [−11.38, −3.25] | ⊕◯◯◯ |
3-h glucose (mg/dl) | 6 | 679 | Mean difference (95%CI) | 0.00 [−11.79, 11.79] | ⊕◯◯◯ |
Family history of diabetes | 6 | 1040 | Odds Ratio (95%CI) | 0.79 [0.50, 1.25] | ⊕⊕◯◯ |
Gestational age at GDM diagnosis (weeks) | 11 | 1473 | Mean difference (95%CI) | 2.64 [1.42, 3.86] | ⊕⊕◯◯ |
Gestation at oral pharmacological agent initiation (weeks) | 7 | 967 | Mean difference (95%CI) | 3.79 [2.08, 5.51] | ⊕⊕◯◯ |
