Fig. 3: Co-circulation of dengue serotypes and serotype dominance. | Communications Medicine

Fig. 3: Co-circulation of dengue serotypes and serotype dominance.

From: Neutralizing antibodies from prior exposure to dengue virus negatively correlate with viremia on re-infection

Fig. 3

a Proportion of samples positive for infecting dengue serotype as determined by nested PCR using total RNA isolated from serum samples is represented by the colours as labelled in the figure: Blue – DENV-1, red-DENV-2, green – DENV-3, purple – DENV4, orange - (DENV-1 + DENV-3) and black - indeterminate serotype. The segregation of serotyping data based on the year of sample collection is shown for (b) 2018 and (c) 2019. d DENV RNA levels in samples segregated as per the infecting serotype is shown. DENV-1: grey, DENV-2:pink, DENV-3:green, DENV-4:dark purple, indeterminate: light purple. Mean rank of each column was compared with mean rank of every other column using non-parametric Kruskal-Wallis test. Correction for multiple comparisons was applied by Dunn’s multiple comparison test. ****P < 0.0001. Error bars in (d) represent Min and Max with range. LOQ is limit of quantitation of the assay. “n” in each of the panels indicates biologically independent samples. P-values are indicated only for observations where the differences are statistically significant.

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