Fig. 5: Long-term response after radiation-induced pseudoprogression.
From: Concurrent gliomas in patients with multiple sclerosis
Representation of isodoses (Gy) and longitudinal MRIs with axial FLAIR images (A) and contrast-enhanced axial T1 images (B) of a patient (p08) with isocitrate dehydrogenase-1 (IDH)-wildtype glioblastoma WHO grade 4. Transient contrast enhancement within the tumor area corresponding to radiation-induced pseudoprogression with a maximum of 8 months after completion of radiotherapy (60/2 Gy) is associated with an increase in subcortical multiple sclerosis lesions (arrows) and the initial diagnosis of a chronic progressive multiple sclerosis course. Long term follow-up shows a moderate generalized brain atrophy (stars) without evidence of glioblastoma recurrence up to 8 years after initial tumor therapy.
