Fig. 1: Representative MRM chromatograms of blood and brain dialysates. | Communications Medicine

Fig. 1: Representative MRM chromatograms of blood and brain dialysates.

From: Transporter modulation of molnupiravir and its metabolite β-D-N4-hydroxycytidine across the blood-brain barrier in a rat

Fig. 1

a blank blood dialysate, b blank blood dialysate spiked with β-D-N4-hydroxycytidine (NHC; 250 ng/mL) and molnupiravir (100 ng/mL), c blood dialysate sample containing NHC (758.5 ng/mL) and molnupiravir (4.6 ng/mL) collected at 140 min after molnupiravir administration (100 mg/kg, i.v.), d blank brain dialysate, e blank brain dialysate spiked with NHC (50 ng/mL) and molnupiravir (25 ng/mL), f brain dialysate sample containing NHC (47.2 ng/mL) and molnupiravir (5.52 ng/mL) collected 60 min after molnupiravir administration (100 mg/kg, i.v.). Peak 1: NHC, Peak 2: molnupiravir.

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