Fig. 6: Integrative analysis of TCR repertoire, TME transcriptome and circulating protein in blood. | Communications Medicine

Fig. 6: Integrative analysis of TCR repertoire, TME transcriptome and circulating protein in blood.

From: Lenvatinib activates anti-tumor immunity by suppressing immunoinhibitory infiltrates in the tumor microenvironment of advanced hepatocellular carcinoma

Fig. 6

a Correlation matrix plot showing coefficients of diversity indexes of TCR repertoire and immune-related signature represented by ssGSEA score. n = 12. b Circos plot showing the strong positive and negative correlation between features of circulating proteins (Luminex) and features of TME transcriptome (nCounter) as indicated by the brown and black links. c Network plot highlighting three clusters including key features from each omics analysis. n = 39 (b, c). TCR T-cell receptor, TME tumor microenvironment, Shannon Shannon-Weaver index H’, Simpson Inv. Simpson’s index 1/λ, Pielou Pielou’s evenness, DE50 Diversity Evenness score.

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