Table 1 Lifetime risk of exposure-induced death % (REID%) statistics for males and females comparing average United States background never-smoker population to clonal hematopoiesis of indeterminate potential (CHIP) carriers for a Mars mission scenario.

From: Considering clonal hematopoiesis of indeterminate potential in space radiation risk analysis for hematologic cancers and cardiovascular disease

Tissue

PE

Median

Q1

Q3

IQR

LW

UW

Unmodified background (males)

 HC

1.42 × 10–1

1.36 × 10–1

9.59 × 10–2

1.93 × 10–1

9.74 × 10–2

1.06 × 10–2

3.39 × 10–1

 CHD

4.94 × 10–1

4.81 × 10–1

3.28 × 10–1

6.86 × 10–1

3.58 × 10–1

1.98 × 10–3

1.22 × 100

 Stroke

2.81 × 10–1

2.67 × 10–1

1.59 × 10–1

4.13 × 10–1

2.54 × 10–1

1.07 × 10–4

7.94 × 10–1

 Total

2.00 × 100

2.00 × 100

1.47 × 100

2.75 × 100

1.28 × 100

7.25 × 10–2

4.67 × 100

CHIP-modified background (males)

 BFO

7.92 × 10–1

3.06 × 10–1

1.14 × 10–1

1.44 × 100

1.32 × 100

9.74 × 10–2

3.41 × 100

 CHD

7.38 × 10–1

7.10 × 10–1

4.60 × 10–1

1.06 × 100

5.98 × 10–1

3.01 × 10–2

1.96 × 100

 Stroke

5.34 × 10–1

4.99 × 10–1

2.83 × 10–1

8.24 × 10–1

5.41 × 10–1

1.43 × 10–4

1.63 × 100

 Total

2.93 × 100

3.01 × 100

2.08 × 100

4.32 × 100

2.24 × 100

5.72 × 10–2

7.68 × 100

Unmodified background (females)

 HC

8.94 × 10–2

8.57 × 10–2

5.97 × 10–2

1.24 × 10–1

6.38 × 10–2

6.39 × 10–3

2.19 × 10–1

 CHD

3.68 × 10–1

3.59 × 10–1

2.45 × 10–1

5.06 × 10–1

2.61 × 10–1

1.99 × 10–3

8.98 × 10–1

 Stroke

3.50 × 10–1

3.33 × 10–1

1.96 × 10–1

5.22 × 10–1

3.26 × 10–1

1.91 × 10–4

1.01 × 100

 Total

2.45 × 100

2.41 × 100

1.69 × 100

3.42 × 100

1.73E × 100

6.27 × 10–2

6.02 × 100

CHIP-modified background (females)

 HC

5.32 × 10–1

2.11 × 10–1

6.89 × 10–2

9.90 × 10–1

9.21 × 10–1

5.94 × 10–3

2.37 × 100

 CHD

5.41 × 10–1

5.20 × 10–1

3.42 × 10–1

7.77 × 10–1

4.36 × 10–1

3.19 × 10–3

1.43 × 100

 Stroke

6.71 × 10–1

6.24 × 10–1

3.54 × 10–1

1.03 × 100

6.76 × 10–1

3.58 × 10–4

2.04 × 100

 Total

3.10 × 100

3.24 × 100

2.24 × 100

4.54 × 100

2.30 × 100

1.90 × 10–1

7.99 × 100

  1. Hematologic cancer (HC), coronary heart disease (CHD), stroke, and solid cancer point estimate (PE), median, first quartile (Q1), third quartile (Q3), inner quartile range (IQR), lower whisker (LW), and upper whisker (UW) of the lifetime REID% distribution for males. Uncertainty propagation was implemented with a Monte Carlo sampling size of N = 100,000. Point estimates of the REID are found by using the most likely values of uncertainty distribution parameters.
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