Fig. 3: Odds ratio (OR, blue) and prevalence (%, red) for the top clinical phenotypes associated with PI, identified in Cohorts 1-2.

a Cohort 1 (N = 1594); (b) Cohort 2 (N = 1594). All clinical phenotypes significantly associated with the diagnosis of PI that had an OR > 1.5 were included in the illustrations. Univariate logistic regression was used to calculate the odds ratios. PD: Physiological development, UNS: Unspecified, NEC: Not elsewhere classified, F: Family, P: Personal, CC: Certain conditions, LH: Lymphoid hematopoietic, C1-C4: Declare congruent phenotypes in Cohorts 1-4.