Fig. 3: Non-negative Matrix Factorization (NMF)-based subpopulation detection associated with survival. | Communications Medicine

Fig. 3: Non-negative Matrix Factorization (NMF)-based subpopulation detection associated with survival.

From: Deep learning and transfer learning identify breast cancer survival subtypes from single-cell imaging data

Fig. 3

a NMF heatmap for 259 patients in our cohort illustrating the seven subpopulations arranged in order of decreasing survival. b Cophenetic Score and Silhouette Coefficient versus the NMF Rank. c Kaplan-Meier (KM) plots illustrate the Overall Survival for patients in the seven NMF-derived subpopulation clusters. d Kaplan-Meier plots illustrate the Overall Survival for patients based on clinicopathological classification. e Heatmap of top-ranked features from best performing two-stage Cox-nnet model, in associations with tumor grade, clinical features and molecular subtypes.

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