Fig. 4: Characterization of the single image-based survival subtypes.
a–r Scoring and profiling for the seven survival subtypes based on various cellular phenotypes and cell-cell interaction features. Cell counts and interactions were normalized between 0 and 1 to make comparison possible on the same scale. a Macrophage2 Cells, b T and B Cells, c Vimentinhi Fibroblasts, d Small Circular Fibroblasts, e Hypoxic Epithelial Cells, f Proliferative Epithelial Cells, g Macrophage2–Vimentinhi Fibroblasts, h T and B Cells–Vimentinhi Fibroblasts, i Macrophage2–Hypoxic Epithelial Cells, j Macrophage2–Proliferative Epithelial Cells, k T and B Cells–Hypoxic Epithelial Cells, l T and B Cells–Proliferative Epithelial Cells, m Macrophage2–Circular Fibroblasts, n Vimentinhi Fibroblasts–Small Circular Fibroblasts, o Vimentinhi Fibroblasts–Hypoxic Epithelial Cells, p Vimentinhi Fibroblasts–Proliferative Epithelial Cells, q Hypoxic Epithelial Cells–Proliferative Epithelial Cells, r Proliferative Epithelial Cells–Proliferative Epithelial Cells. Statistical testing was done for n = 259 patients using the Mann-Whitney U Test with Benjamini-Hochberg-based false discovery rate (FDR) adjustment. The significant pairs are marked as follows: *: p-value < 0.01. **: 0.01 < p-values < 0.05. Each violin is drawn using the kernel density estimate of the underlying distribution. s Circos plots demonstrate the correlation between feature pairs associated with each subpopulation.
