Table 3 Cohort Performance: The assay performance in the entire data set (top) or the out-of-sample Test set (bottom) are indicated along with the 95% confidence intervals calculated using the Clopper-Pearson interval
From: Description of an activity-based enzyme biosensor for lung cancer detection
Entire Data Set (n = 750) | |||||
|---|---|---|---|---|---|
| Â | Spec Max | Spec Bias | Ensemble | Sens Bias | Sens Max |
Sensitivity | 61% | 63% | 84% | 85% | 96% |
95% CI | 55–68% | 57–70% | 79–89% | 80–89% | 92–98% |
Specificity | 86% | 86% | 81% | 80% | 57% |
95% CI | 83–89% | 83–89% | 77–84% | 76–83% | 52–61% |
NPV | 84% | 85% | 92% | 93% | 97% |
PPV | 66% | 65% | 64% | 64% | 48% |
Accuracy | 79% | 79% | 82% | 81% | 68% |
95% CI | 76–82% | 76–82% | 79–84% | 79–84% | 65–72% |
Validation Set data (n = 250) | |||||
Sensitivity | 62% | 62% | 90% | 91% | 97% |
95% CI | 49–73% | 49–73% | 80–96% | 82–97% | 90–100% |
Specificity | 86% | 85% | 82% | 82% | 54% |
95% CI | 80–91% | 79–90% | 76–88% | 75–87% | 47–62% |
NPV | 86% | 86% | 96% | 96% | 98% |
PPV | 63% | 61% | 66% | 65% | 44% |
Accuracy | 80% | 79% | 84% | 84% | 66% |
95% CI | 74–84% | 73–84% | 79–89% | 79–89% | 60–72% |
