Fig. 1: Overview of IL-2 related Treg biology and therapeutic hypothesis of an IL-2Rα biased IL-2 for Treg expansion and activation.
From: A CD25-biased interleukin-2 for autoimmune therapy engineered via a semi-synthetic organism
a Normal Treg biology showing opposing pleiotropic effects of IL-2. b Schematic representation of an IL-2Rα biased IL-2 for therapeutic expansion and activation of Treg cells and induction of immune suppressive effects along with reduced stimulation of CD8 + T and NK cells. CD8 cluster of differentiation 8, IL-2 interleukin-2, IL-2Rα interleukin-2 receptor alpha chain, IL-2Rβ interleukin-2 receptor beta chain, IL-2Rγ interleukin-2 receptor gamma chain, NK natural killer, PEG polyethylene glycol, PEG-IL-2 pegylated interleukin-2, PSTAT5 phosphorylated Signal Transducer and Activator of Transcription 5, Teff effector T cell, Treg regulatory T cell.
