Fig. 3: H16 administration stimulates increased Treg expression of markers that correlate with Treg identity, activation and suppressive function.
From: A CD25-biased interleukin-2 for autoimmune therapy engineered via a semi-synthetic organism
H16 (0.9 mg/kg) was administered via tail vein injection to C57BL/6 mice, and peripheral blood was recovered at intervals post dose. Multi-color flow cytometry was used to profile individual cell populations. The expression of CD25 (a), FoxP3 (b), Helios (c), ICOS (d), and Ki67 (e) are shown (mean ± SEM for three individual animals at each point). CD25 cluster of differentiation 25, FoxP3 forkhead box protein 3, ICOS inducible T-cell co-stimulator, Ki67 Kiel 67, (proliferation marker), MFI median fluorescence intensity, SEM standard error of mean, Treg regulatory T cell.
