Table 1 PK profile of H16 conjugated to 30 and 50 kDa PEG in NHP following SC administration
From: A CD25-biased interleukin-2 for autoimmune therapy engineered via a semi-synthetic organism
Variant | NHP # | AUClast/dose (h*kg*ng/mL/mg) | Cmax/dose (kg*ng/mL/mg) | t1/2 (h) |
|---|---|---|---|---|
H16 30 kDa | 1 | 183,000 | 3,990 | 17.6 |
2 | 133,000 | 2,200 | 16.8 | |
3 | 142,000 | 2,840 | 17.0 | |
H16 50 kDa | 1 | 410,000 | 4,710 | 28.8 |
2 | 429,000 | 5,300 | 27.0 | |
3 | 728,000 | 14,300 | 28.1 |
