Fig. 3: Elimination and metabolic profiles of 14C-A947 following intravenous administration of 14C-A947 (4 mg/kg and 200 µCi/kg) in rats. | Communications Medicine

Fig. 3: Elimination and metabolic profiles of 14C-A947 following intravenous administration of 14C-A947 (4 mg/kg and 200 µCi/kg) in rats.

From: Tissue distribution and retention drives efficacy of rapidly clearing VHL-based PROTACs

Fig. 3

a Mean cumulative percent of radioactive dose in urine, bile, and feces of bile-cannulated (BDC) animals (n = 3) (solid circle, urine; hollow reverse triangle, feces; solid square, bile; solid triangle, total). The mean and standard deviation (SD) are plotted with individual numerical data listed in Supplementary Table 2. b HPLC radioactivity profiles in urine, bile and feces. c Structures of 14C-A947 metabolites in urine, bile, and feces of rats.

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