Fig. 7: PROTAC tissue distribution study design and analysis.
From: Tissue distribution and retention drives efficacy of rapidly clearing VHL-based PROTACs
This includes quantitative whole-body autoradiograph (QWBA, the blood calibration standards were ~2300, 750, 250, 75, 25, 5, and 1.5 nCi/g), MALDI-imaging mass spectrometry (MALDI-IMS), or tissue excision for mass spectrometry, tissue and plasma drug concentration asymmetry as shown in PROTAC concentration-time profiles in tissues and plasma, and potential applications in target tissues using less frequent intravenous administration.
