Table 1 Demographics and Baseline Characteristics
Characteristic | Familial hypercholesterolemia, N = 518a | Non-Familial hypercholesterolemia, N = 389a |
|---|---|---|
Sex | ||
 Man | 223 (43%) | 234 (60%) |
 Woman | 295 (57%) | 155 (40%) |
 Age (years) | 60 (53, 68) | 65 (56, 71) |
Laboratory values | ||
Total cholesterol, mmol/L | 6.59 (5.50, 7.80) | 5.66 (4.92, 6.38) |
Unknown | 63 | 117 |
LDL levels, mmol/L | 4.36 (3.43, 5.41) | 3.41 (2.79, 4.00) |
Unknown | 73 | 132 |
HDL levels, mmol/L | 1.28 (1.08, 1.56) | 1.22 (0.99, 1.47) |
Unknown | 63 | 116 |
Triglycerides, mmol/L | 1.82 (1.26, 2.63) | 2.00 (1.25, 2.96) |
Unknown | 64 | 117 |
Lipid modifying drugs | ||
Any statins | 272 (53%) | 175 (45%) |
High dose statins | 136 (26%) | 85 (22%) |
Moderate dose statins | 73 (14%) | 51 (13%) |
Low dose statins | 63 (12%) | 39 (10%) |
Fibrates | 44 (8.5%) | 43 (11%) |
Bile acid sequestrants | 34 (6.6%) | 16 (4.1%) |
Ezetimibe | 369 (71%) | 240 (62%) |
Number of lipid modifying drugs | ||
 0 drugs | 75 (14%) | 58 (15%) |
 1 drug | 189 (36%) | 200 (51%) |
 2+ drugs | 254 (49%) | 131 (34%) |
Comorbidities | ||
Atherosclerotic cardiovascular disease | 295 (57%) | 309 (79%) |
Coronary heart disease | 252 (49%) | 274 (70%) |
Atherosclerotic cerebrovascular disease | 56 (11%) | 47 (12%) |
Peripheral artery disease | 52 (10%) | 61 (16%) |
Chronic obstructive pulmonary disease | 48 (9.3%) | 53 (14%) |
Heart failure | 45 (8.7%) | 58 (15%) |
Rheumatoid arthritis | 15 (2.9%) | 14 (3.6%) |
Cancer, ex. non-melanoma skin cancer | 46 (8.9%) | 28 (7.2%) |
Chronic kidney disease | 17 (3.3%) | 12 (3.1%) |
Hypertension | 265 (51%) | 277 (71%) |
Diabetes mellitus | 75 (14%) | 85 (22%) |
Diabetes mellitus with organ damage | 51 (9.8%) | 56 (14%) |
