Fig. 4: Results of CIITA^+/+ or CIITA^-/- monkey iPSC-RPE cell transplantation.

a, b Monkey HM-22 transplanted with CIITA^+/+ wild type miPSC-RPE cells (a) and monkey HM-23 transplanted with CIITA^-/- MHC-class II knockout miPSC-RPE cells (b) were examined by color funds photograph (left), FAF (middle) and OCT (right) at 1, 3, and 6 months after transplantation. The left insert of the OCT is a navigation window that indicates the scanning position: OCT image was obtained by scanning along the red line; yellow dot (which is sometimes in a hidden mode) corresponds to the yellow line in the OCT image; when continuous scanning mode is used (usually when the grafted area is not clear), green and red lines indicate the series of scanning position, of which the red line indicates the layer of the OCT image shown; whether the shown OCT image is the vertical or horizontal red line-layer is indicated by the yellow dot (although the yellow dot is sometimes in a hidden mode). In (a), graft (white arrows)-related rejection with cell infiltration (yellow arrows) was suspected. In (b), grafts (white arrows) were clearly shown and became sheet-like without symptoms of immune rejection at least for 6 months. White arrows: RPE grafts; dashed line circle in FAF: transplanted area.