Table 4 Summary of post-booster Geometric Mean Titers (GMT) and Geometric Mean Titer ratio (GMTR) and associated 95% CI in Sanofi MVB.1.351, BNT162b2 and Sanofi MVD614 vaccine booster groups by SARS-CoV-2 infection status subgroup and by variant strain
Sanofi MVB.1.351 (N = 54) | BNT162b2 (N = 60) | Sanofi MVD614 (N = 48) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Subgroup: SARS CoV-2 Status | Strain | Time Point | M | GMT/ GMTR | (95%CI)a | M | GMT/ GMTR | (95%CI) | M | GMT/ GMTR | (95%CI) |
SARS CoV- 2 Uninfected up to 3 months post-booster | Omicron BA.1 | D28 M3 M3/D28 | 45 45 45 | 1320 840 0.64 | (950;1834) (593;1191) (0.53;0.77) | 42 37 37 | 557 287 0.43 | (431;721) (208;398) (0.35;0.53) | 46 46 44 | 587 362 0.67 | (434;794) (248;529) (0.55;0.81) |
Omicron BA.4/5 | D28 M3 M3/D28 | 45 42 42 | 949 656 0.61 | (689;1307) (454;946) (0.50;0.75) | 40 38 36 | 426 177 0.44 | (309;587) (117;266) (0.34;0.56) | 47 46 45 | 438 250 0.57 | (301;637) (163;381) (0.46;0.72) | |
D614 | D28 M3 M3/D28 | 45 45 45 | 6241 4257 0.68 | (4760;8183) (3146;5761) (0.58;0.81) | 42 42 42 | 4900 2260 0.46 | (3887;6177) (1702;3002) (0.37;0.55) | 48 48 48 | 5163 3370 0.65 | (3927;6788) (2468;4601) (0.55;0.78) | |
SARS CoV-2 Infection between Day 28 and Month 3 | Omicron BA.1 | D28 M3 M3/D28 | 9 9 9 | 1365 4722 3.46 | (894;2085) (2351;9484) (1.51;7.93) | 16 18 16 | 446 2016 4.60 | (296;674) (983;4137) (2.06;10.3) | 0 0 0 | NC NC NC | |
Omicron BA.4/5 | D28 M3 M3/D28 | 9 9 9 | 814 1972 2.42 | (408;1624) (857;4534) (1.21;4.86) | 18 18 18 | 270 1128 4.18 | (163;446) (550;2313) (2.15;8.12) | 0 0 0 | NC NC NC | ||
D614 | D28 M3 M3/D28 | 9 9 9 | 7665 18367 2.40 | (4654;12623) (8700;38772) (1.17;4.92) | 18 18 18 | 3710 9057 2.44 | (2474;5562) (4940;16607) (1.38;4.31) | 0 0 0 | NC NC NC | ||
