Table 1 Comparison of plasma biochemistry and body composition (DXA) of individuals with LRP5 gain-of-function (GoF) (A242T, N198S) and LRP5 loss-of-function (LoF) (V667M) variants and age, sex and BMI-matched controls

From: LRP5 promotes adipose progenitor cell fitness and adipocyte insulin sensitivity

 

LRP5 GoF

LRP5 LoF

 

Mean difference (95% CI)

P value

Mean difference (95% CI)

P value

Sex, case (controls)

4F, 2M (40F, 20M)

 

15F, 8M (150F, 79M)

 

Age (years)a

2.5 ± 8.3

 

0.7 ± 2.8

 

BMI (kg/m2)a

−0.08 ± 0.20

 

−0.01 ± 0.04

 

Z-height

0.89 (0.09, 1.69)

0.029

−0.45 (−0.86, −0.04)

0.030

Z-weight

0.88 (0.08, 1.68)

0.032

−0.45 (−0.86, −0.04)

0.030

DXA measurementsb

 Z-Fat android

−0.49 (−1.31, 0.32)

0.23

0.05 (−0.48, 0.59)

0.84

 Z-Fat gynoid

0.23 (−0.60, 1.06)

0.23

−0.51 (−1.03, 0.02)

0.057

 Z-Fat visceral

−0.30 (−1.13, 0.52)

0.47

0.09 (−0.44, 0.62)

0.73

 Z-Fat legs

0.89 (0.09, 1.69)

0.029

−0.59 (−1.11, −0.06)

0.028

 Z-Total fat mass

0.45 (−0.37, 1.27)

0.28

−0.10 (−0.63, 0.43)

0.71

 Z-Total fat percentage

−0.23 (−1.06, 0.59)

0.57

−0.16 (−0.69, 0.37)

0.55

 Z-Android/leg fat ratio

−1.05 (−1.40, −0.70)

3.29 × 10−6 c

0.42 (−0.10, 0.95)

0.11

 Z-Total lean mass

0.34 (−0.48, 1.16)

0.41

−0.00 (−0.53, 0.53)

0.99

 Z-Lean mass legs

0.12 (−0.71, 0.95)

0.77

0.02 (−0.51, 0.56)

0.93

 Z-Total BMD

3.11 (2.99, 3.24)

2.18 × 10−25 c

−0.73 (−1.24, −0.21)

0.006

Biochemistry

 Z-glucose (fasting)

−0.96 (−1.75, −0.16)

0.019

−0.11 (−0.53, 0.30)

0.58

 Z-insulin (fasting)

−0.92 (−1.71, −0.12)

0.025

0.40 (−0.01, 0.81)

0.06

 Z-HOMA-IR

−0.92 (−1.72, −0.13)

0.024

0.39 (−0.02, 0.79)

0.06

 Z-HOMA-B

−0.63 (−1.05, −0.21)

0.006c

0.34 (−0.07, 0.75)

0.11

 Z-NEFA

−0.24 (−1.07, 0.59)

0.57

0.24 (−0.17, 0.65)

0.25

 Z-Adipo-IR

−0.81 (−1.25, −0.38)

0.001c

0.36 (−0.05, 0.77)

0.09

 Z-triglycerides

−0.58 (−1.39, 0.24)

0.16

0.38 (−0.03, 0.79)

0.07

  1. Absolute values are shown in Supplementary Tables 3 and 5. Data represent mean difference (case-control) in outcome (Z-transformed) for each case within the cluster of ten age, sex and BMI-matched controls.
  2. Adipo-IR adipose tissue insulin resistance, BMD bone mineral density, BMI body mass index, CI confidence interval, DXA dual-energy X-ray absorptiometry, HOMA-IR Homeostatic Model Assessment for Insulin Resistance, HOMA-B Homeostatic Model Assessment for Insulin Secretion, NEFA non-esterified fatty acids.
  3. aRepresent mean and SD of the case from its controls within each cluster.
  4. bFor LoF, DXA measurements were calculated for 14 cases (10F, 4M) and their matched 139 controls on whom data were available.
  5. cP value obtained by two-sample t-test (cwith Welch’s correction for unequal variance).
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