Table 1 Patient characteristics
From: Deep proteome profiling of metabolic dysfunction-associated steatotic liver disease
Clinical feature | Liver | scWAT | oWAT | Initial plasma | Validation plasma (n = 41) | |
|---|---|---|---|---|---|---|
(n = 58) | (n = 58) | (n = 27) | (n = 143) | (n = 28) | (n = 13) | |
Gender (% female) | 65.5 | 65.5 | 74.1 | 78.3 | 78.6 | 69.2 |
Age (years) | 47.5 ± (13.6) | 46.0 ± (13.5) | 45.0 ± (11.9) | 46.0 ± (12.3) | 54.0 ± (11.8) | 47.0 ± (14.7) |
BMI (kg m−2) | 42.6 ± (6.9) | 41.5 ± (6.9) | 41.1 ± (4.3) | 41.1 ± (6.0) | 39.8 ± (3.1) | 28.8 ± (3.0) |
Body fat (%) | 49.9 ± (5.7) | 49.3 ± (5.6) | NA | 48.5 ± (5.6) | 47.8 ± (4.8) | 37.8 ± (8.6) |
Kleiner fibrosis grade | ||||||
F0 | 13 | 10 | 6 | 39 | 6 | 5 |
F1 | 31 | 33 | 16 | 69 | 15 | 8 |
F2 | 11 | 10 | 3 | 25 | 6 | 0 |
F3 | 3 | 4 | 1 | 7 | 1 | 0 |
F4 | 0 | 1 | 1 | 3 | 0 | 0 |
SAF diagnosis | ||||||
No MASLD | 12 | 16 | 13 | 39 | 9 | 13 |
MASL | 29 | 30 | 11 | 74 | 14 | 0 |
MASH | 17 | 12 | 3 | 30 | 5 | 0 |
Steatosis | ||||||
0 | 12 | 16 | 13 | 39 | 9 | 13 |
1 | 22 | 27 | 12 | 60 | 11 | 0 |
2 | 17 | 9 | 1 | 28 | 7 | 0 |
3 | 7 | 6 | 1 | 16 | 1 | 0 |
Hepatocellular ballooning | ||||||
0 | 41 | 46 | 24 | 112 | 23 | 13 |
1 | 16 | 12 | 3 | 29 | 4 | 0 |
2 | 1 | 0 | 0 | 2 | 1 | 0 |
Lobular inflammation | ||||||
0 | 13 | 18 | 13 | 49 | 11 | 12 |
1 | 31 | 28 | 11 | 71 | 16 | 1 |
2 | 11 | 12 | 3 | 21 | 1 | 0 |
3 | 3 | 0 | 0 | 2 | 0 | 0 |
