Fig. 2: The post-operative DCP trend and DCP dynamic rate.
From: Des-γ-carboxy Prothrombin in hepatocellular carcinoma post-operative recurrence risk evaluation
a The average trend of serum DCP from pre-operative to two years post-operative in 1074 patients of the Exploration Cohort (n = 6207 DCP measurements), the shaded areas around the lines indicate the 95% confidence intervals. b Post-operative DCP concentrations measured within two years. Red represents all post-operative DCP, and blue represents the last DCP before recurrence (n for all post-operative DCP = 5133 and n for the last DCP before recurrence = 498). c Three latent post-operative DCP trajectories: stable (blue), rapid rising (red), and slow rising (purple). The risk table below illustrates the percentage of recurrent patients at 5, 10, 15, and 20 months (n = 5133 DCP measurements), the shaded areas around the lines indicate the 95% confidence intervals. d The Kaplan–Meier curves of RFS according to the three DCP trajectories (log-rank test) (n = 1074 HCC patients), the shaded areas around the lines indicate the 95% confidence intervals. e The average trend of serum DCP over two years post-operatively, the shaded areas around the lines indicate the 95% confidence intervals. The median time of the first four DCP measurements were 1.2, 3.6, 6.7, and 10.0 months. The first four DCP measurements were analyzed for Rate1 (between DCP1 and DCP2), Rate2 (between DCP2 and DCP3), and Rate3 (between DCP3 and DCP4) (n = 5133 DCP measurements). f The Kaplan–Meier curves of RFS according to whether the rates were greater than 0.8% per day (log-rank test) (n = 1074 HCC patients). g The Kaplan–Meier curves of RFS using the DCP dynamic rate as a time-varying covariate (log-rank test) (n = 2567 DCP dynamic rates).
