Fig. 3: The relationship between DCP dynamic rate and recurrence.
From: Des-γ-carboxy Prothrombin in hepatocellular carcinoma post-operative recurrence risk evaluation
a The bar plot showing the percentage of patients with recurrence within three and six months after surgeries. “−−” represents DCP dynamic rates ≤ 0.8% per day and DCP concentrations <40 mAU ml−1. “−+” indicates that either the DCP dynamic rates or DCP concentrations exceeded the threshold. “++” represents that both values exceeded the thresholds (n = 2567 measurements combining DCP dynamic rate and DCP concertation). b The Kaplan–Meier curves of RFS according to whether the DCP dynamic rates and DCP concentrations exceeded their respective thresholds (log-rank test) (n = 1074 HCC patients). c The Kaplan–Meier curves of RFS using the DCP dynamic rate and DCP concentrations as a time-varying covariate (log-rank test) (n = 2567 measurements combining DCP dynamic rate and DCP concertation). d Confusion matrix showing DCP performance for classifying recurrence. Positive: either or both the DCP dynamic rates or DCP concentrations exceeded the thresholds. Negative: neither exceeded the thresholds (n = 2567 measurements combining DCP dynamic rate and DCP concertation). e The Kaplan–Meier curves comparing RFS between patients with consistently positive DCP levels after the first positive results and those whose status reverted to negative (log-rank test) (n = 209 measurements combining DCP dynamic rate and DCP concertation). f The bar plot showing the percentage of patients with recurrence within three and six months in the Validation Cohort (n = 318 measurements combining DCP dynamic rate and DCP concertation). g The Kaplan–Meier curves of RFS in the validation cohort according to whether the DCP dynamic rates and DCP concentrations exceeded their respective thresholds in the Validation Cohort (log-rank test) (n = 263 HCC patients).
