Table 1 Characteristics of the overall population (HBOC), BRCA1 P/LPV carriers and BRCA2 P/LPV carriers
HBOC 87 patients | BRCA1 P/LPV carriers 32 patients | BRCA2 P/LPV carriers 47 patients | BRCA1 Vs BRCA2 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
Mean | SD | Miss. | Mean | SD | Miss. | Mean | SD | Miss. | p-value | |
Age | 32.31 | 5.73 | 0 | 32.31 | 5.33 | 0 | 32.17 | 6.32 | 0 | 0.914 |
Hormonal contraceptive use (years) | 5.76 | 5.72 | 40 (46%) | 5.25 | 5.22 | 12 (38%) | 5.67 | 6.50 | 25 (53%) | 0.819 |
Menarche (years) | 12.26 | 1.48 | 0 | 11.95 | 1.40 | 0 | 12.40 | 1.54 | 0 | 0.182 |
Length of menstrual cycle (days) | 28.18 | 2.35 | 9 (10%) | 28.10 | 2.11 | 3 (9%) | 28.14 | 2.66 | 5 (11%) | 0.945 |
BMI | 23.52 | 4.39 | 1 (1%) | 23.98 | 3.88 | 0 | 22.94 | 4.81 | 1 (2%) | 0.292 |
AMH (ng/ml) | 2.62 | 1.86 | 1 (1%) | 2.92 | 2.06 | 0 | 2.43 | 1.75 | 1 (2%) | 0.278 |
AFC (n) | 16.20 | 9.97 | 2 (2%) | 16.06 | 9.02 | 0 | 15.98 | 10.96 | 2 (4%) | 0.971 |
N | Perc. | Miss. | N | Perc. | Miss. | N | Perc. | Miss. | ||
Previous pregnancies (n) | 0 | 0 | 0 | 0.946 | ||||||
0 | 44 | 50.57 | 16 | 50.00 | 25 | 53.19 | ||||
1 | 13 | 14.94 | 5 | 15.63 | 7 | 14.89 | ||||
2 | 21 | 24.14 | 9 | 28.13 | 10 | 21.28 | ||||
3 | 5 | 5.75 | 1 | 3.13 | 3 | 6.38 | ||||
4 | 4 | 4.60 | 1 | 3.13 | 2 | 4.26 | ||||
Previous deliveries (n) | 0 | 0 | 0 | 0.936 | ||||||
0 | 48 | 55.17 | 18 | 56.25 | 26 | 55.32 | ||||
1 | 16 | 18.39 | 6 | 18.75 | 9 | 19.15 | ||||
2 | 19 | 21.84 | 7 | 21.88 | 9 | 19.15 | ||||
3 | 3 | 3,45 | 1 | 3.13 | 2 | 4.26 | ||||
4 | 1 | 1.15 | 0 | 0.00 | 1 | 2.13 | ||||
Previous termination of pregnancy (n) | 0 | 0 | 0 | 0.883 | ||||||
0 | 70 | 80.46 | 26 | 81.25 | 40 | 85.11 | ||||
1 | 12 | 13.79 | 5 | 15.63 | 5 | 10.64 | ||||
2 | 5 | 5.75 | 1 | 3.13 | 2 | 4.26 | ||||
Current smoking | 0 | 0 | 0 | 0.518 | ||||||
No | 71 | 81.61 | 24 | 75.00 | 40 | 85.11 | ||||
Yes | 16 | 18.39 | 8 | 25.00 | 7 | 14.89 | ||||
Family history of premature menopause | 0 | 0 | 0 | 0,178 | ||||||
No | 80 | 91.95 | 29 | 90.63 | 43 | 91.49 | ||||
Yes | 7 | 8.05 | 3 | 9.38 | 4 | 8.51 | ||||
Prophylactic surgery | 0 | 0 | 0 | 1,000 | ||||||
None | 79 | 90.80 | 28 | 87.50 | 43 | 91.49 | ||||
Mastectomy | 6 | 6.90 | 3 | 9.38 | 3 | 6.38 | ||||
Salpingectomy | 1 | 1.15 | 0 | 0.00 | 1 | 2.13 | ||||
Mastectomy and salpingectomy | 1 | 1,.15 | 1 | 3.13 | 0 | 0.00 | ||||
