Table 2 Linear mixed effects models of CI and CIV levels in single muscle fibers in individuals with PD and controls

From: Mitochondrial complex I deficiency occurs in skeletal muscle of a subgroup of individuals with Parkinson’s disease

 

Dependent variable

 

log(NDUFB10/VDAC1)

log(MTCO1/VDAC1)

Predictors

B

95% CI

P value

B

95% CI

P value

Disease state (PD)

−0.016

−0.047 to 0.014

0.290

−0.010

−0.050 to 0.029

0.609

Age

−0.002

−0.003 to −1.2e−04

0.034

−0.002

−0.004 to 2.5e−04

0.026

Sex (Male)

0.019

−0.007 to 0.045

0.153

0.052

0.018–0.086

0.003

Smoking

−0.005

−0.057 to 0.047

0.849

−0.020

−0.089 to 0.048

0.564

Batch (Batch 2)a

−0.102

−0.126 to −0.078

6.9e−17

0.064

0.032 to 0.095

7.0e–05

Random Effects

σ2

0.004

0.007

τ00 Subject

0.003

0.006

ICC

0.479

0.439

n Subject

92

92

Observations

9073

9073

Marginal R2/Conditional R2

0.305/0.638

0.107/0.499

  1. log(NDUFB10/VDAC1) complex I level adjusted for mitochondrial content, log(MTCO1/VDAC1) complex IV level adjusted for mitochondrial content, B regression coefficient (unstandardized), 95% CI 95% confidence interval of the regression coefficient, σ2 residual variance, τ00 Subject random intercept variance, ICC intraclass correlation coefficient, representing the proportion of total variance in the dependent variable attributable to the grouping structure (i.e, subjects), n Subject number of study subjects.
  2. Significant P values are in bold. Nominal P values are given.
  3. aImmunohistochemistry staining was performed in two batches.