Table 2 Comparison of piperacillin’s detection limit using different reference samples

From: Impact of clinical preparation steps and use of sex-specific reference for accurate antibiotic monitoring in body fluids

Reference

LoD/µM (mg/L)

LoQ/µM (mg/L)

own urine f

27.3 (14.7)

82.8 (44.7)

pool f

30.9 (16.7)

93.5 (50.4)

pool m

64.0 (34.5)

194 (105)

pool mix

36.6 (19.7)

111 (59.9)

  1. Comparison of the limit of detection and quantification (LoD and LoQ) of piperacillin using different references. In all cases, the values were within the range of clinically relevant concentrations (25,238 ± 15,200) µM [(13,062 ± 7867) mg/L]. Since the dilution series was prepared in female urine, the female’s own urine and female pool provided the lowest LoD. Using a male and mixed pool, the LoDs increase by 25% and 57%, respectively. It is therefore recommended to use a sex-specific pool if the original pool is not available.
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