Fig. 1: Principal Component Analysis (PCA) of the CHRIS plasma proteome data reveals that proteomes of young women cluster into two distinct groups, which are attributable to the use of hormonal contraceptives. | Communications Medicine

Fig. 1: Principal Component Analysis (PCA) of the CHRIS plasma proteome data reveals that proteomes of young women cluster into two distinct groups, which are attributable to the use of hormonal contraceptives.

From: Extensive modulation of the circulating blood proteome by hormonal contraceptive use across two population studies

Fig. 1

a Grouping of individuals on PC1 and PC2. Women (red) and men (blue) are distinguished by color. A distinct cluster of women separates from the main bulk of male and female participants, particularly along PC1, indicating the presence of a subgroup of female study participants with a strong characteristic plasma proteome. b PCA loadings on PC1 and PC2. Each arrow represents a protein, with its length and direction indicating the protein’s contribution to the respective principal component, highlighting the proteins most influential in driving variance. c Relationship between PC1 (x-axis) and participant’s age (y-axis). The cluster of women on PC1 is clearly enriched with young women below the age of 40.

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