Fig. 4: Hormonal contraceptive use is strongly affecting the circulating blood proteome of women below the age of 40 in two independent cohorts. | Communications Medicine

Fig. 4: Hormonal contraceptive use is strongly affecting the circulating blood proteome of women below the age of 40 in two independent cohorts.

From: Extensive modulation of the circulating blood proteome by hormonal contraceptive use across two population studies

Fig. 4

Volcano plots illustrating the association between protein abundances and hormonal contraceptive use in the CHRIS a and the BASE-II d cohort. The sample sizes are n = 729 and n = 240, respectively. Each point represents one protein, red coloring indicates significant association. b and e Abundance of the protein angiotensinogen (AGT) in study participants taking hormonal contraceptives (HCU) and women and men that don’t in the CHRIS b or the BASE-II e study. Samples sizes for the 3 groups are 316, 1,623, and 1,533 in CHRIS and 91, 149, and 197 in BASE-II. c ROC (Receiver Operating Characteristics) curve demonstrating the high predictive power of AGT for HCU. f Comparison of effect sizes of all proteins for association with HCU in CHRIS and BASE-II; the solid black line represents the identity line. Correlation of data points: Spearman’s rho = 0.91.

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