Table 4 Select associations of symptoms and diagnoses with increased and decreased odds of developing uterine fibroids within race
From: A phenome-wide association study of uterine fibroids reveals a marked burden of comorbidities
Phecode | Description | Meta-Analysis Non-Hispanic Black Individuals | Meta-Analysis Non-Hispanic White Individuals | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phecode cases | Phecode controls | OR (95% CI) | P value | I² | I² p value | Phecode cases | Phecode controls | OR (95% CI) | P value | I² | I² p value | ||
Genitourinary | |||||||||||||
599.3 | Dysuria | 794 | 7692 | 1.77 (1.50, 2.09) | 8.99E−12 | 56.4 | 0.13 | 5370 | 46,382 | 2.01 (1.88, 2.16) | 1.86E-87 | 0 | 0.55 |
614 | Inflammatory diseases of female pelvic organs | 2209 | 6733 | 2.34 (2.09, 2.62) | 1.18E−48 | 0 | 0.69 | 4950 | 54,054 | 2.43 (2.27, 2.60) | 2.30E−143 | 95.3 | 3.98E−06 |
614.3 | Pelvic inflammatory disease | 235 | 6733 | 3.25 (2.47, 4.28) | 3.25E−17 | 0 | 0.37 | 449 | 54,054 | 3.77 (3.07, 4.63) | 8.98E−37 | 88.2 | 3.64E−03 |
615 | Endometriosis | 216 | 6733 | 9.51 (6.91, 13.08) | 1.30E−43 | 0 | 0.49 | 1201 | 54,054 | 7.66 (6.75, 8.70) | 5.84E−217 | 96.5 | 1.11E−07 |
618 | Genital prolapse | 101 | 10,740 | 3.90 (2.54, 5.99) | 5.14E−10 | 0 | 0.98 | 1586 | 64,222 | 3.53 (3.17, 3.94) | 3.53E−112 | 2.6 | 0.17 |
622 | Polyp of female genital organs | 195 | 9922 | 12.86 (8.68, 19.0) | 3.80E−37 | 42.4 | 0.19 | 1439 | 61,486 | 7.54 (6.70, 8.48) | 4.18E−247 | 137.0 | 6.40E−30 |
625 | Pain and other symptoms associated with female genital organs | 1278 | 7217 | 2.75 (2.41, 3.14) | 2.92E−50 | 0 | 0.41 | 5925 | 50,331 | 3.09 (2.90, 3.29) | 5.41E−263 | 5.6 | 0.12 |
626 | Disorders of menstruation and other abnormal bleeding from female genital tract | 3476 | 4716 | 7.33 (6.50, 8.26) | 1.50E−232 | 62.8 | 0.10 | 16090 | 31775 | 6.27 (5.93, 6.63) | 7.48E-901 | 167.3 | 2.76E−35 |
628 | Ovarian cyst | 750 | 4716 | 7.19 (6.01, 8.58) | 1.60E−104 | 0 | 0.45 | 4902 | 31775 | 6.56 (6.09, 7.06) | 1.08E−533 | 98.9 | 5.01E−21 |
Endocrine-Metabolic | |||||||||||||
261 | Vitamin deficiency | 966 | 8938 | 1.92 (1.66, 2.22) | 2.15E−18 | 79.9 | 0.03 | 8579 | 51,216 | 1.31 (1.24, 1.39) | 1.26E−20 | 92.6 | 2.36E−04 |
261.4 | Vitamin D deficiency | 871 | 8938 | 2.00 (1.71, 2.33) | 7.74E−19 | 86.2 | 0.01 | 7737 | 51,216 | 1.36 (1.28, 1.44) | 1.57E−23 | 94.7 | 1.31E−05 |
272 | Disorders of lipid metabolism | 1671 | 8681 | 1.38 (1.22, 1.57) | 4.78E−07 | 0 | 0.49 | 17,519 | 44,911 | 1.49 (1.41, 1.56) | 8.69E−54 | 86.0 | 7.56E−03 |
276 | Disorders of fluid, electrolyte, & acid-base balance | 1998 | 7481 | 0.74 (0.66, 0.83) | 4.25E−07 | 12.4 | 0.29 | 9702 | 50,387 | 0.67 (0.63, 0.71) | 1.36E−35 | 97.3 | 1.49E−09 |
278 | Overweight | 2772 | 7190 | 1.35 (1.21, 1.51) | 2.35E−07 | 49 | 0.16 | 13127 | 48,291 | 1.57 (1.48, 1.66) | 9.90E−54 | 97.3 | 1.04E−09 |
278.4 | Abnormal weight gain | 335 | 7190 | 2.13 (1.67, 2.71) | 1.29E−09 | 0 | 0.34 | 1872 | 48,291 | 1.89 (1.70, 2.11) | 7.52E−31 | 50.6 | 0.15 |
Neoplasm | |||||||||||||
180 | Cervical cancer and dysplasia | 767 | 5969 | 7.27 (5.95, 8.87) | 2.40E-84 | 0 | 0.57 | 1938 | 44,949 | 8.21 (7.21, 9.35) | 3.57E−221 | 0 | 0.48 |
182 | Malignant neoplasm of uterus | 41 | 6830 | 247.62 (59.00, 1039.22) | 5.02E−14 | 0 | 0.99 | 379 | 48,250 | 247.70 (181.69, 337.67) | 1.94E−266 | 98.0 | 1.14E−12 |
218 | Benign neoplasm of uterus | 1896 | 6878 | 11,741.68 (3402.88, 40514.86) | 9.39E−50 | 0 | 0.78 | 7129 | 49293 | 4404.58 (3315.61, 5851.21) | 7.26E−731 | 67.7 | 0.08 |
220 | Benign neoplasm of ovary | 88 | 6689 | 20.23 (13.04, 31.38) | 4.86E−41 | 81.5 | 0.02 | 309 | 46,765 | 27.17 (21.24, 34.76) | 5.10E−152 | 87.4 | 4.91E−03 |
Symptoms | |||||||||||||
760 | Back pain | 2208 | 7318 | 1.36 (1.23, 1.52) | 1.42E−08 | 0.3 | 0.32 | 13,783 | 45,285 | 1.45 (1.38, 1.52) | 1.36E−51 | 0 | 0.80 |
761 | Cervicalgia | 822 | 9256 | 1.85 (1.59, 2.16) | 3.23E−15 | 0 | 0.49 | 5805 | 56,083 | 1.56 (1.47, 1.67) | 4.62E−44 | 97.1 | 3.21E−09 |
764 | Sciatica | 173 | 9893 | 2.24 (1.61, 3.12) | 1.97E−06 | 0 | 0.75 | 2071 | 58,128 | 1.68 (1.51, 1.86) | 2.68E−22 | 0 | 0.85 |
798 | Malaise and fatigue | 2413 | 6642 | 1.33 (1.19, 1.48) | 1.73E−07 | 61.8 | 0.11 | 14,649 | 42,016 | 1.44 (1.37, 1.51) | 7.05E−51 | 86.9 | 5.82E−03 |
Respiratory | |||||||||||||
464 | Acute sinusitis | 761 | 6565 | 2.35 (1.98, 2.78) | 3.92E−23 | 65.8 | 0.09 | 11015 | 39,837 | 2.16 (2.05, 2.28) | 7.91E−171 | 80.9 | 0.02 |
475 | Chronic sinusitis | 333 | 7606 | 2.21 (1.75, 2.79) | 2.45E−11 | 0 | 0.97 | 3276 | 44,659 | 1.91 (1.76, 2.08) | 3.04E−52 | 56.8 | 0.13 |
Hematopoietic | |||||||||||||
280 | Iron deficiency anemias | 1017 | 5766 | 2.17 (1.88, 2.51) | 2.44E−25 | 0 | 0.47 | 4195 | 46,765 | 1.65 (1.53, 1.78) | 4.39E−36 | 91.8 | 4.62E−04 |
Neurological | |||||||||||||
327 | Sleep disorders | 651 | 9305 | 1.86 (1.56, 2.21) | 3.02E−12 | 0 | 0.87 | 6544 | 53,877 | 1.54 (1.45, 1.64) | 6.82E−43 | 79.9 | 3.00E−02 |
327.32 | Obstructive sleep apnea | 471 | 9305 | 1.55 (1.26, 1.89) | 2.66E−05 | 6.5 | 0.30 | 2614 | 53,877 | 1.44 (1.31, 1.58) | 4.66E−14 | 95.5 | 2.17E−06 |
340 | Migraine | 565 | 7353 | 1.83 (1.52, 2.21) | 2.76E−10 | 0 | 0.96 | 4852 | 52,553 | 1.51 (1.41, 1.62) | 1.91E−30 | 0 | 0.55 |
Dermatological | |||||||||||||
694 | Dyschromia and Vitiligo | 823 | 56704 | 1.87 (1.60, 2.19) | 5.95E−15 | 23.9 | 0.25 | ||||||
701 | Other hypertrophic & atrophic conditions of skin | 339 | 9950 | 1.90 (1.51, 2.38) | 4.73E−08 | 0 | 0.32 | 2637 | 58,821 | 2.04 (1.86, 2.23) | 3.05E−53 | 0 | 0.63 |
704.1 | Alopecia | 154 | 9779 | 2.81 (2.00, 3.94) | 2.84E−09 | 0 | 0.42 | 1002 | 59,398 | 1.58 (1.36, 1.83) | 7.90E−10 | 59.0 | 0.12 |