Table 4 Select associations of symptoms and diagnoses with increased and decreased odds of developing uterine fibroids within race

From: A phenome-wide association study of uterine fibroids reveals a marked burden of comorbidities

Phecode

Description

Meta-Analysis Non-Hispanic Black Individuals

Meta-Analysis Non-Hispanic White Individuals

Phecode cases

Phecode controls

OR (95% CI)

P value

p value

Phecode cases

Phecode controls

OR (95% CI)

P value

p value

Genitourinary

599.3

Dysuria

794

7692

1.77 (1.50, 2.09)

8.99E−12

56.4

0.13

5370

46,382

2.01 (1.88, 2.16)

1.86E-87

0

0.55

614

Inflammatory diseases of female pelvic organs

2209

6733

2.34 (2.09, 2.62)

1.18E−48

0

0.69

4950

54,054

2.43 (2.27, 2.60)

2.30E−143

95.3

3.98E−06

614.3

Pelvic inflammatory disease

235

6733

3.25 (2.47, 4.28)

3.25E−17

0

0.37

449

54,054

3.77 (3.07, 4.63)

8.98E−37

88.2

3.64E−03

615

Endometriosis

216

6733

9.51 (6.91, 13.08)

1.30E−43

0

0.49

1201

54,054

7.66 (6.75, 8.70)

5.84E−217

96.5

1.11E−07

618

Genital prolapse

101

10,740

3.90 (2.54, 5.99)

5.14E−10

0

0.98

1586

64,222

3.53 (3.17, 3.94)

3.53E−112

2.6

0.17

622

Polyp of female genital organs

195

9922

12.86 (8.68, 19.0)

3.80E−37

42.4

0.19

1439

61,486

7.54 (6.70, 8.48)

4.18E−247

137.0

6.40E−30

625

Pain and other symptoms associated with female genital organs

1278

7217

2.75 (2.41, 3.14)

2.92E−50

0

0.41

5925

50,331

3.09 (2.90, 3.29)

5.41E−263

5.6

0.12

626

Disorders of menstruation and other abnormal bleeding from female genital tract

3476

4716

7.33 (6.50, 8.26)

1.50E−232

62.8

0.10

16090

31775

6.27 (5.93, 6.63)

7.48E-901

167.3

2.76E−35

628

Ovarian cyst

750

4716

7.19 (6.01, 8.58)

1.60E−104

0

0.45

4902

31775

6.56 (6.09, 7.06)

1.08E−533

98.9

5.01E−21

Endocrine-Metabolic

261

Vitamin deficiency

966

8938

1.92 (1.66, 2.22)

2.15E−18

79.9

0.03

8579

51,216

1.31 (1.24, 1.39)

1.26E−20

92.6

2.36E−04

261.4

Vitamin D deficiency

871

8938

2.00 (1.71, 2.33)

7.74E−19

86.2

0.01

7737

51,216

1.36 (1.28, 1.44)

1.57E−23

94.7

1.31E−05

272

Disorders of lipid metabolism

1671

8681

1.38 (1.22, 1.57)

4.78E−07

0

0.49

17,519

44,911

1.49 (1.41, 1.56)

8.69E−54

86.0

7.56E−03

276

Disorders of fluid, electrolyte, & acid-base balance

1998

7481

0.74 (0.66, 0.83)

4.25E−07

12.4

0.29

9702

50,387

0.67 (0.63, 0.71)

1.36E−35

97.3

1.49E−09

278

Overweight

2772

7190

1.35 (1.21, 1.51)

2.35E−07

49

0.16

13127

48,291

1.57 (1.48, 1.66)

9.90E−54

97.3

1.04E−09

278.4

Abnormal weight gain

335

7190

2.13 (1.67, 2.71)

1.29E−09

0

0.34

1872

48,291

1.89 (1.70, 2.11)

7.52E−31

50.6

0.15

Neoplasm

180

Cervical cancer and dysplasia

767

5969

7.27 (5.95, 8.87)

2.40E-84

0

0.57

1938

44,949

8.21 (7.21, 9.35)

3.57E−221

0

0.48

182

Malignant neoplasm of uterus

41

6830

247.62 (59.00, 1039.22)

5.02E−14

0

0.99

379

48,250

247.70 (181.69, 337.67)

1.94E−266

98.0

1.14E−12

218

Benign neoplasm of uterus

1896

6878

11,741.68 (3402.88, 40514.86)

9.39E−50

0

0.78

7129

49293

4404.58 (3315.61, 5851.21)

7.26E−731

67.7

0.08

220

Benign neoplasm of ovary

88

6689

20.23 (13.04, 31.38)

4.86E−41

81.5

0.02

309

46,765

27.17 (21.24, 34.76)

5.10E−152

87.4

4.91E−03

Symptoms

760

Back pain

2208

7318

1.36 (1.23, 1.52)

1.42E−08

0.3

0.32

13,783

45,285

1.45 (1.38, 1.52)

1.36E−51

0

0.80

761

Cervicalgia

822

9256

1.85 (1.59, 2.16)

3.23E−15

0

0.49

5805

56,083

1.56 (1.47, 1.67)

4.62E−44

97.1

3.21E−09

764

Sciatica

173

9893

2.24 (1.61, 3.12)

1.97E−06

0

0.75

2071

58,128

1.68 (1.51, 1.86)

2.68E−22

0

0.85

798

Malaise and fatigue

2413

6642

1.33 (1.19, 1.48)

1.73E−07

61.8

0.11

14,649

42,016

1.44 (1.37, 1.51)

7.05E−51

86.9

5.82E−03

Respiratory

464

Acute sinusitis

761

6565

2.35 (1.98, 2.78)

3.92E−23

65.8

0.09

11015

39,837

2.16 (2.05, 2.28)

7.91E−171

80.9

0.02

475

Chronic sinusitis

333

7606

2.21 (1.75, 2.79)

2.45E−11

0

0.97

3276

44,659

1.91 (1.76, 2.08)

3.04E−52

56.8

0.13

Hematopoietic

280

Iron deficiency anemias

1017

5766

2.17 (1.88, 2.51)

2.44E−25

0

0.47

4195

46,765

1.65 (1.53, 1.78)

4.39E−36

91.8

4.62E−04

Neurological

327

Sleep disorders

651

9305

1.86 (1.56, 2.21)

3.02E−12

0

0.87

6544

53,877

1.54 (1.45, 1.64)

6.82E−43

79.9

3.00E−02

327.32

Obstructive sleep apnea

471

9305

1.55 (1.26, 1.89)

2.66E−05

6.5

0.30

2614

53,877

1.44 (1.31, 1.58)

4.66E−14

95.5

2.17E−06

340

Migraine

565

7353

1.83 (1.52, 2.21)

2.76E−10

0

0.96

4852

52,553

1.51 (1.41, 1.62)

1.91E−30

0

0.55

Dermatological

694

Dyschromia and Vitiligo

      

823

56704

1.87 (1.60, 2.19)

5.95E−15

23.9

0.25

701

Other hypertrophic & atrophic conditions of skin

339

9950

1.90 (1.51, 2.38)

4.73E−08

0

0.32

2637

58,821

2.04 (1.86, 2.23)

3.05E−53

0

0.63

704.1

Alopecia

154

9779

2.81 (2.00, 3.94)

2.84E−09

0

0.42

1002

59,398

1.58 (1.36, 1.83)

7.90E−10

59.0

0.12

  1. *OR odds ratio, CI confidence interval.