Fig. 5: Estimation of the associations of baseline antibody levels on re-infection risk in individuals with hybrid immunity.
a, b The conditional effects of anti-N antibody levels and anti-S antibody titers during the observation period on the absolute risk of re-infection in individuals with hybrid immunity at baseline. Each predicted data point (blue dots), along with the median absolute risk (line) and 95% CredIs (ribbon), is shown. The overall risk of a control group with no vaccination or prior infection history in this cohort (0.184) (green solid line) and the 90% reduction of relative risk (i.e., 10% relative risk [10%RR]) (green dotted line) are shown. c The combined effect of anti-N antibody levels and anti-S antibody titers during the observation period on the absolute risk of re-infection. The logarithmic absolute risk of infection is indicated by the color bar. The white dotted and solid lines show the log10 absolute risk decrease for every 0.5 and 1.0, respectively. n = 990. d, e The conditional effects of anti-N antibody levels and BA.5 NT during the observation period on the absolute risk of re-infection in subsampled individuals with hybrid immunity at baseline. Each predicted data point (blue dots), along with the median absolute risk (line) and 95% CredIs (ribbon), is shown. f The combined effect of anti-N antibody level and BA.5 NT during the observation period on the absolute risk of re-infection. The logarithmic absolute risk of infection is indicated by the color bar. The white dotted and solid lines show the log10 absolute risk decrease for every 0.5 and 1.0, respectively. n = 73.
