Fig. 4: Gene augmentation therapy in Otof E1799del/E1799del mice restores acoustic startle responses.
From: Cochlear gene therapy restores hearing and auditory processing in an atypical DFNB9 mouse model
A Acoustic startle responses were assessed with acoustic pulse-alone stimulations (60–110 dB) in P60 control mice (black, n = 10, 6 females and 4 males), Otof E1799del/E1799del mice treated on P2 (orange, n = 8, 4 females and 4 males) or mice treated on P30 (teal, n = 12, 5 females and 7 males) and untreated Otof E1799del/E1799del mice (purple, n = 12, 8 females and 4 males). B Prepulse inhibition responses of P60 control mice (black, n = 10), Otof E1799del/E1799del mice treated on P2 (orange, n = 8) or on P30 (teal, n = 12), and untreated Otof E1799del/E1799del mice (purple, n = 12). Pulses were presented alone or with a 60 dB SPL prepulse. Note the decrease in the response to the pulse in the presence of the prepulse for control and treated mice. The data are presented as the mean ± SEM. ****p < 0.0001, ***p < 0.001, *p < 0.05 (two-way ANOVA test followed by a Bonferroni’s multiple comparison post hoc test).
