Table 1 17α-Estradiol decreases body weight, food intake, and fat mass while increasing lean mass more strongly in male APOE4 mice. All data show mean ± standard deviation

From: Protection against APOE4-associated phenotypes with the longevity-promoting intervention 17α-estradiol in middle-aged male mice

Measure

APOE3 Control

APOE3 17αE2

APOE4 Control

APOE4 17αE2

Body Mass % change from Week 0

2.18 ± 1.65

−6.22 ± 0.79

−2.92 ± 1.69

−17.22 ± 1.75

(−7.16 ± 2.52) p = 0.035

(−15.09 ± 2.52) p < 0.0001

Food Intake kcal

14.13 ± 0.63

13.54 ± 0.46

14.37 ± 0.39

12.82 ± 0.72

(−4.10 ± 3.93)

(−10.82 ± 4.52)

p < 0.0001

Week 20 Lean Mass % of Body Mass

59.67 ± 6.50

65.97 ± 2.95

53.00 ± 4.37

62.36 ± 4.88

(+5.02)

(+8.12) p = 0.0001

Week 20 Fat Mass % of Body Mass

27.67 ± 9.36

20.19 ± 4.26

36.94 ± 7.11

25.87 ± 6.39

(−15.62)

(−17.63) p = 0.0001

  1. (Number in parentheses indicates % change relative to genotype-matched control).
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