Table 1 Results for all Tier 1 pathogen-disease pairs and other discussed pairs

From: A survey of pathogenic involvement in non-communicable human diseases

Disease name

ICD10

Path

Group

UKB FDR

TNX FDR

UKB OR

TNX OR

Rep status

Anogenital Herpesviral Infect

A60

HSV-2

Tier 1

1.4E−03

2.6E−298

4.10

11.76

REP

Herpesviral Infect

B00

HSV-1

Tier 1

9.5E−04

8.9E−266

2.08

2.93

REP

Herpesviral Infect

B00

HSV-2

Tier 1

2.2E−01

1.6E−298

1.36

5.18

REP

Herpes Zoster

B02

VZV

Tier 1

6.4E−02

4.1E−259

1.43

14.43

REP

Unspec Viral Hepatitis

B19

HBV

Tier 1

2.4E−04

1.9E−299

2.28

7.20

REP

Unspec Viral Hepatitis

B19

HCV

Tier 1

6.7E−06

1.9E−299

2.96

11.57

REP

Unspec HIV

B24

HIV

Tier 1

1.3E−06

8.0E−300

38.21

635.37

REP

Infectious Mono

B27

EBV

Tier 1

5.0E−02

8.2E−212

2.14

8.39

REP

Iron-Deficiency Anemia

D50

H. pylori

Tier 2

9.9E−03

1.1E−08

1.17

1.24

REP

Multiple Sclerosis

G35

EBV

Tier 2

2.5E−01

2.5E−03

2.55

4.45

REP

Duodenal Ulcer

K26

H. pylori

Tier 2

1.3E−03

1.7E−04

1.73

1.43

REP

Peptic Ulcer Site Unspec

K27

H. pylori

Tier 2

9.0E−02

5.6E−138

1.60

3.68

REP

Gastritis and Duodenitis

K29

H. pylori

Tier 2

1.5E−01

7.9E−134

1.13

1.97

REP

Fibrosis and Cirrhosis of Liver

K74

HCV

Tier 2

7.3E−02

6.7E−299

2.69

4.31

REP

Other Dis of Liver

K76

HBV

Tier 2

1.6E−02

7.8E−299

1.44

2.97

REP

Other Dis of Liver

K76

HCV

Tier 2

1.6E−02

7.8E−299

1.47

2.03

REP

Asthma

J45

H. pylori

Unk

1.8E−02

2.8E−04

0.89

0.80

REP

GERD

K21

H. pylori

Unk

2.1E−02

2.9E−07

0.88

0.66

REP

Other Dis of Esophagus

K22

H. pylori

Unk

5.1E−03

1.4E−09

0.68

0.72

REP

Diaphragmatic Hernia

K44

H. pylori

Unk

2.7E−01

1.4E−06

0.90

0.76

REP

Inflammatory Bowel Dis

K58

H. pylori

Unk

1.9E−01

6.10E−29

0.91

0.48

REP

Crohn’s Dis

K50

CMV

Unk

8.7E−01

–

0.86

–

DNAR

Crohn’s Dis

K50

EBV

Unk

8.7E−01

–

1.65

–

DNAR

Ulcerative Colitis

K51

CMV

Unk

2.0E−01

8.6E−06

1.36

2.78

REP

Ulcerative Colitis

K51

EBV

Unk

3.7E−01

–

0.80

–

DNAR

Unspec Noninfective Gastroenteritis/Colitis

K52

CMV

Unk

8.4E−01

–

0.97

–

DNAR

Unspec Noninfective Gastroenteritis/Colitis

K52

EBV

Unk

8.4E−01

–

1.04

–

DNAR

Systemic Lupus Erythematosus

M32

EBV

Tier 2

1.8E−01

1.4E−21

3.98

4.96

REP

Systemic Lupus Erythematosus

M32

CMV

Unk

4.0E−01

–

1.89

–

DNAR

  1. The disease name with its 3-character International Classification of Diseases 10th revision (ICD10) code is listed next to the paired pathogen, followed by the electronic health record statistical analysis results, including the UK Biobank (UKB) per-disease false discovery rate (FDR) and odds ratio (OR), as well as the TriNetX (TNX) per-disease FDR and OR. All eight of the Tier 1 pathogen-disease pairs and any other pairs discussed are listed.
  2. Column abbreviations: Path Pathogen, Group Control group (Tier 1 control, Tier 2 control, or previously Unknown association (Unk)). Disease name abbreviations: Infect Infection, Unspec Unspecified, Mono Mononucleosis, Dis Disease, GERD Gastroesophageal reflux disease. Replication Status (Rep Status) abbreviations: REP Replicated (UKB per-disease FDR < 0.3 AND TNX per-disease FDR < 0.01), DNAR Did not attempt replication (UKB per-disease FDR > 0.3).
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