Fig. 3: Profibrotic signaling of LOY-leukocytes in men with IPF. | Communications Medicine

Fig. 3: Profibrotic signaling of LOY-leukocytes in men with IPF.

From: Mosaic loss of chromosome Y in blood is associated with male susceptibility for idiopathic pulmonary fibrosis

Fig. 3

Results from single-cell transcriptomics analysis on combined datasets from Morse et al., Reyfman et al., Adams et al., Habermann et al., and de Rooij et al. a shows results from the differential gene expression analysis comparing loss of chromosome Y (LOY) cells and wild-type (WT) cells sampled from Idiopathic Pulmonary Fibrosis (IPF) patients. Genes within MSY and genes related to inflammation and fibrosis are labeled in the plot. b presents immunological processes enriched in LOY-leukocytes identified using Gene Ontology (GO) terms while c shows enrichment of TGF-signaling in specific leukocyte lineages. d displays expression levels of the profibrotic genes FN1 and SPP1 in macrophages from healthy, non-IPF (COPD/COVID) and IPF lung dissociates. e displays altered ligand-receptor interactions between LOY-leukocytes and other cell types in healthy, non-IPF (COPD/COVID) and IPF, showing all signaling pathways with significant activity as represented by relative interaction strength from minimum activity to maximum activity compared to all interactions. In f, the correlation between the percentage of LOY-leukocytes and fibroblast activation in IPF patients is presented. Significant differences are denoted as: ****p < 0.0001, **p < 0.01, *p < 0.05.

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