Fig. 7: Antibody-dependent phagocytosis of EPCR-binding IT4VAR19 IEs opsonised with plasma from children with malaria. | Communications Medicine

Fig. 7: Antibody-dependent phagocytosis of EPCR-binding IT4VAR19 IEs opsonised with plasma from children with malaria.

From: A whole blood assay for antibody dependent phagocytosis of Plasmodium falciparum infected erythrocytes

Fig. 7

ADP of IEs by neutrophils (a,b) and monocytes (c,d) in whole blood was performed three times with different donors. ADP is represented as the mean of these three individual donors (dots) for each tested sample, and medians of each group are indicated with horizontal bars. Results are expressed as relative phagocytosis in arbitrary units (AU), the percentage of the pooled immune plasma (PPS). 462 plasma samples from children from PNG were tested; phosphate buffered saline (PBS) was included as a negative control. a and c uncomplicated malaria at presentation (UM_acute, n = 79), uncomplicated malaria in convalescence (UM_convalescent, n = 86), severe malaria at presentation (SM_acute, n = 211), and severe malaria in convalescence (SM convalescent, n = 86) children. Mann Whitney-U Test. b and d analysis of paired acute and convalescent plasma samples from 43 children with uncomplicated malaria and 75 children with severe malaria. Wilcoxon matched pairs rank test.

Back to article page