Fig. 2: Cumulative incidence plots for ischemic events according to whole-brain, periventricular and deep WMHs in MMD patients.

N = 151. A Ischemic events rate according to whole-brain WMHs. Black line (Q1): WMHs <6217 mm3; red line (Q2): WMHs ≥6217 mm3, B ischemic events rate according to the PWMHs. Black line (Q1): WMHs <4280 mm3; red line (Q2): WMHs ≥4280 mm3, C ischemic events rate according to the DWMH. Black line (Q1): WMHs <2570 mm3; red line (Q2): WMHs ≥2570 mm3, D receiver operating characteristic (ROC) curves of quantitative analysis compared with the Fazekas grade to distinguish ischemic events. The maximum Youden index occurred when the cutoff of the PVWMHs was 4280 mm3. MMD moyamoya disease, Q1 quartile 1, Q2 quartile 2, TIA transient ischemic attack, WMH white matter hyperintensity, q quantitative, PVWMH periventricular white matter hyperintensity, DWMH deep white matter hyperintensity.