Fig. 4: ΔUrate associated with DNAmbaseline in a sex-specific manner and urate change-associated CpG sites were related to human metabolism. | Communications Medicine

Fig. 4: ΔUrate associated with DNAmbaseline in a sex-specific manner and urate change-associated CpG sites were related to human metabolism.

From: Sex-specific DNA methylation associations with circulating urate levels and BCG-induced urate changes

Fig. 4

a Schematic representation of the analyses. b The Manhattan plot showing the results from EWAS of Δurateshort in all participants (1), females (2), and males (3) respectively. The CpG sites were ordered by their chromosomal position on the x-axis with their -log10 (P value) of the association on the y-axis. Colorful dot: significant CpG sites, grey dot: non-significant CpG sites. c The scatter plot showing the distribution of -log10 (P value) * sign(effect estimate) of the significant sites from EWAS of Δurateshort in males and females. Color represented the significant sites from different sex groups. Bar plot describing the KEGG enrichment categories of genes annotated to the significant CpG sites identified from the EWAS of ΔUrateshort in females (d) or males (e). “BETA < 0” represented the significant sites with a negative effect estimate. “BETA > 0” represented the significant sites with a positive effect estimate. f One example of the replicated urate change-associated CpG site. The y-axis represented the urate change from day90 minus day0 and after rank normalization. The x-axis represented the beta value of cg04372321.

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