Fig. 6: The increase in urate levels following vaccination is not unique to BCG, and it may be influenced by shifts in purine metabolism.
a Spearman’s correlation between ΔUratelong and baseline hormone level (after age correction). b Boxplot showing the plasma urate concentration at different time points, color indicating different sex groups. The paired samples Wilcoxon test was used to compare the urate level among different time points (n = 165 independent individuals, 3 time points paired). Wilcoxon rank sum test was used to compare the difference between males and females. ns: not significant, *P < 0.05, **P < 0.01, ***P < 0.005, ****: P < 0.001. c The mean difference of metabolites level between each two time points (n = 165 independent individuals, 3 time points paired). These metabolites are all that we can find from the purine metabolism pathway. Stars represented the significance of the difference using paired samples Wilcoxon test. *: P < 0.05, **P < 0.01, ***P < 0.005, ****P < 0.001.
