Fig. 1: Differentially expressed genes and enriched pathways in active endometrium from UF patients. | Communications Medicine

Fig. 1: Differentially expressed genes and enriched pathways in active endometrium from UF patients.

From: A systems-based approach to uterine fibroids identifies differential splicing associated with abnormal uterine bleeding

Fig. 1

a Principal component analysis (PCA) plot showing clustering of endometrium samples from UF patients with or without heavy menstrual bleeding (HMB) symptoms (n = 15; proliferative phase: 4 HMB and 4 non-HMB; secretory phase: 4 HMB and 3 non-HMB). b Bar plots of pathways enriched in HMB endometrium, identified by gene set enrichment analysis (GSEA). Pathways are ranked by adjusted p-value, shown in a gradient of blue to red. Left and right panels correspond to the proliferative and secretory phase, respectively. c Network visualisation of differentially expressed genes (DEGs; absolute log2FC ≥ 1.5, padj < 0.05) in secretory HMB endometrium, depicting the linkages of gene functions and pathway associations. d Boxplots of IL11 and LIF expression in the proliferative (left panel) and secretory (right) phases of the endometrium.

Back to article page