Fig. 3: Comparative analysis of transcript usage in active endometrium from patients with heavy menstrual bleeding or MED12-mutated fibroids. | Communications Medicine

Fig. 3: Comparative analysis of transcript usage in active endometrium from patients with heavy menstrual bleeding or MED12-mutated fibroids.

From: A systems-based approach to uterine fibroids identifies differential splicing associated with abnormal uterine bleeding

Fig. 3

a Boxplots displaying the expression of differentially used transcript variants in the active endometrium of UF patients with heavy menstrual bleeding (HMB, n = 8; coloured in pink-orange) compared to non-HMB patients (n = 7; grey). The centre line represents the median, while the lower and upper hinges correspond to the 25th and the 75th percentiles. b, c Bar plots of enriched pathways associated with genes exhibiting differential transcript usage, identified using DRIMSeq (p-value < 0.05) and stageR (OFDR < 0.05). b Pathways enriched in HMB versus non-HMB endometrium. c Pathways enriched in endometrium from MED12-mutant versus MED12 wild-type (WT) fibroid patients. d Boxplots showing the expression of differentially used transcript variants in active endometrium from MED12-mutant UF patients (n = 10; pink-orange) versus MED12 WT (n = 5; grey). e Ribbon plots illustrating transcript usage shifts between MED12 WT and MED12-mutant conditions, highlighting dynamic usage patterns across transcript variants of individual genes. Each transcript per gene is represented by a distinct colour.

Back to article page