Table 1 Common cancer-associated neomers

From: Leveraging sequences missing from the human genome to diagnose cancer

Neomer

Locus

Coordinate (hg38)

Mutation

Name

Patient #

Cancer #

AGGGCCCGGAAGGGGC

TERT

chr5:1295113

G > A

−124C > T C228T

97

7

TCTTGCCTACGCCATC

KRAS

chr12:25245350

C > T

c.35G > AGly12Asp

89

6

CTGTTGGCGTAGGCAA

KRAS

chr12:25245350

C > A

c.35G > TGly12Val

79

6

ACGCCACGAGCTCCAA

KRAS

chr12:25245351

C > G

c.34G > T Gly12Cys

47

1

GGTGCATGTTTGTGCC

TP53

chr17:7673802

C > T

c.818G > A Arg273Pro

35

13

GTGGGGGCAGTGCCTC

TP53

chr17:7675088

C > T

c.524G > A Arg175His

28

11

  1. Six of the most common neomers created by a single mutation. The nucleotide in bold font and underlined is the neomer causing mutation.
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