Table 1 Demographics of physio-cognitive decline and control participants among NILS-LSA, LAST, and ILAS cohorts included in the metabolomics analysis

From: Data from multi-national aging cohorts show dysregulated metabolic pathways in people with physio-cognitive decline

 

NILS-LSA7

LAST1

ILAS3

 

Control

PCD

P

Control

PCD

P

Control

PCD

P

n

61

61

 

101

101

 

35

35

 

Age (years)

73.2 ± 4.7

75.3 ± 4.9

0.0191

68.9 ± 2.9

70.0 ± 3.6

0.0187

72.5 ± 4.4

73.8 ± 5.0

0.2506

Sex ratio (% male)

45.9

45.9

1

29.7

29.7

1

40.0

40.0

1

Education (years)

12.3 ± 2.3

10.5 ± 2.3

3.97E-05

15.4 ± 3.0

14.1 ± 3.2

0.0028

10.3 ± 4.6

0.5 ± 1.1

1.08E-14

Smoking, n (%)

4 (6.6)

4 (6.6)

1

3 (3.0)

3 (3.0)

1

0 (0.0)

3 (8.6)

0.0767

Drinking, n (%)

35 (57.4)

23 (37.7)

0.0296

65 (64.4)

58 (57.4)

0.3128

3 (8.6)

5 (14.3)

0.4524

Disease history

Hypertension, n (%)

24 (39.3)

26 (42.6)

0.7127

29 (28.7)

33 (32.7)

0.5417

10 (28.6)

19 (54.3)

0.0290

Diabetes, n (%)

6 (9.8)

7 (11.5)

0.7692

6 (5.9)

18 (17.8)

0.0091

4 (11.4)

11 (31.4)

0.0414

Osteoporosis, n (%)

10 (16.4)

9 (14.8)

0.8028

19 (18.8)

29 (28.7)

0.0983

1 (2.9)

0 (0.0)

0.2920

CKD, n (%)

3 (4.9)

0 (0.0)

0.0795

2 (2.0)

3 (3.0)

0.6507

0 (0.0)

1 (2.9)

0.3138

COPD, n (%)

0 (0.0)

0 (0.0)

NA

10 (9.9)

5 (5.0)

0.1797

0 (0.0)

0 (0.0)

NA

CVD, n (%)

3 (4.9)

6 (9.8)

0.2988

2 (2.0)

4 (4.0)

0.4072

1 (2.9)

0 (0.0)

0.3138

CAD, n (%)

6 (9.8)

5 (8.2)

0.7519

7 (6.9)

9 (8.9)

0.6023

3 (8.6)

1 (2.9)

0.3031

Physical performance

Walking speed (m/s)

1.43 ± 0.14

1.15 ± 0.16

1.32E−17

–

–

–

1.05 ± 0.17

0.59 ± 0.18

8.76E-17

Grip strength (kg)

30.7 ± 8.5

23.6 ± 7.8

4.85E-06

29.3 ± 8.0

22.9 ± 7.3

1.27E−08

30.7 ± 8.1

24.5 ± 6.6

9.11E-04

5 time sit-to-stand (s)

–

–

–

7.6 ± 2.1

11.1 ± 3.6

4.79E−15

–

–

–

Cognitive function

MMSE

29.3 ± 0.5

25.9 ± 1.1

2.54E−38

–

–

–

29.5 ± 0.5

19.3 ± 2.7

6.98E-23

MoCA

–

–

–

29.4 ± 0.5

26.5 ± 0.5

3.26E-99

–

–

–

  1. Continuous variables are represented as means ± standard deviation. PCD physio-cognitive decline, CKD chronic kidney disease, COPD chronic obstructive pulmonary disease, CVD cardiovascular disease, CAD coronary artery disease, MMSE Mini-Mental State Examination, MoCA Montreal Cognitive Assessment, NA not applicable. P values are obtained from either student t-tests or Pearson chi-square tests.
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